Random bits

I will be migrating future content on this blog to a new URL, http://randombits.workingagenda.com. I will also be changing the CMS from WordPress to Drupal 7.

The U.S. Bureau of Labor Statistics publishes National Industry-Specific Occupational Employment and Wage Estimates.

The BLS estimated 24,580 persons were employed as “Computer and Information Research Scientists” in 41 states. The employment occupation code is 15-1111.

52 percent of all jobs were in 5 states: California, Virginia, Maryland, Texas and Massachusetts. (more…)

KEI is interested in the development of sustainable mechanisms to strengthen the evidence for public policy decisions. One element of this work concerns user generated databases, an area of considerable interest, but mixed experience, in recent years. The following are examples of several such projects, beginning with the excellent Ensembl project, followed by several others of varying degrees of success in their implementation.

As this brief list shows, there are all sorts of ways to design and manage user generated databases. In some cases, the database services seem to be set up more to showcase a technology or an idea for a platform. In other cases, the database is a focused effort to solve a practical and well identified user interest. Some are run by for profit companies, others by non-profits, individuals or communities. The databases take different approaches in terms of database design, attention to standards for data formats, and governance, among other issues.

The Ensembl Project

The Ensembl project produces genome databases for vertebrates and other eukaryotic species, and makes this information freely available online. The Ensembl project was started in 1999, some years before the draft human genome was completed. Even at that early stage it was clear that manual annotation of 3 billion base pairs of sequence would not be able to offer researchers timely access to the latest data. The goal of Ensembl was therefore to automatically annotate the genome, integrate this annotation with other available biological data and make all this publicly available via the web. Since the website’s launch in July 2000, many more genomes have been added to Ensembl and the range of available data has also expanded to include comparative genomics, variation and regulatory data.

The number of people involved in the project has also steadily increased. Currently, the Ensembl group consists of between 40 and 50 people, divided in a number of teams. (more…)

Among large bio-pharmaceutical firms, Gilead is an outlier in terms of market cap per employee. (more…)

In terms of market cap and revenue per employee, Apple and Google are in another class.
(more…)

The chart below presents the 2011 2nd quarter revenue per employee for the 12 largest bio pharmaceutical firms.

The unweighted average was $146,235.86. The median was $135,712. Amgen has the largest ratio of $227,660
in 2nd quarter revenue per employee. (more…)

Pfizer’s 2010 Financial Report for investors covers a number of topics.

Where does Pfizer sell its drugs? The U.S. represented 42.8 percent of Pfizer’s 2010 sales. Western Europe and Scandinavian countries were 24.6 percent. Australia, New Zealand, Canada, Japan, and South Korea were 14.9 percent. Together, these high income countries were 82.3 percent of Pfizer’s 2010 sales.

Pfizer calls the other Asian countries, plus Africa, Latin America, and Eastern Europe, “emerging markets.” This segment had 17.7 percent of Pfizer sales in 2010, up from 14.9 percent in 2008. In 2010, the “emerging markets” were 72 percent of the sales in Western Europe and Scandinavia, and growing at a faster rate. (more…)

In 1997, the Orphan Drug Tax Credit was made permanent. In 1998, $80.4 million in credits were claimed on tax returns. By 2008, the claimed credits totaled $450.2 million. This represents a compound growth rate of 17 percent per year. Over the eleven year period, the IRS reported total credits of $2.3355 billion. This is not much when you consider that the orphan tax credit covers 50 percent of the cost of qualifying clinical trials. During the period from January 1, 1997 to December 31, 2008, the FDA granted 1163 orphan designations for which the credit applied. In the same period, the FDA gave marketing approval to 183 indications. On a per-approval basis, that works out to 2335.5/183 = $12.8 million per indication that received FDA marketing approval.

It is also useful to note that there were 6.4 indications for each one receiving marketing approval — a useful statistic regarding the hazard rate for orphan products. (more…)

Today Paul Miano published this report: Cancer: Approval, ownership, market structure, and placement on WHO Model Essential Medicines List, for 100 new molecular entities (NMEs) on the NCI alpha list of cancer drugs and vaccines, KEI Research Note 2011:1.

One of the findings of the report: ownership of cancer drugs sold as a monopoly is concentrated in six countries. And, 85 percent of patented cancer drugs are owned by firms from the US, the UK and Switzerland. (more…)

Before Google Plus, I spent a fair amount of time updating Facebook and twitter. Since Google Plus became available, I initially have found myself focusing less on twitter. I don’t make much use of the G+ circles, but I do like the ability to follow people and comment on their posts, and have people comment on mine. I also like the fact that I am not bound by limits on the number of characters I enter, even though I initially thought this would be a negative.